Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex

Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex

Abstract Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergistically cytotoxic in human CRC cells. Combination of the TOP1 inhibitor irinotecan or it...

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Bibliographic Details
Main Authors: Yilun Sun, Simone A. Baechler, Xiaohu Zhang, Suresh Kumar, Valentina M. Factor, Yasuhiro Arakawa, Cindy H. Chau, Kanako Okamoto, Anup Parikh, Bob Walker, Yijun P. Su, Jiji Chen, Tabitha Ting, Shar-yin N. Huang, Erin Beck, Zina Itkin, Crystal McKnight, Changqing Xie, Nitin Roper, Deepak Nijhawan, William Douglas Figg, Paul S. Meltzer, James C. Yang, Craig J. Thomas, Yves Pommier
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39374-9

Internet

https://doi.org/10.1038/s41467-023-39374-9

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