Characterization of fenugreek and its natural compounds targeting AKT-1 protein in cancer: Pharmacophore, virtual screening, and MD simulation techniques

Characterization of fenugreek and its natural compounds targeting AKT-1 protein in cancer: Pharmacophore, virtual screening, and MD simulation techniques

Objective: Cancer is the second biggest cause of death in humans. Rapid advancements in clinical bioinformatics and high-throughput proteomics technology are essential tools and methodologies for cancer research. Medicinal plants are considered operative therapeutic agents that are utilized for nove...

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Bibliographic Details
Main Authors: Hafiz Muhammad Ahmad, Muhammad Abrar, Osheen Izhar, Imran Zafar, Mohd Ashraf Rather, Amer M. Alanazi, Abdul Malik, Ahmar Rauf, Mashooq A. Bhat, Tanveer A. Wani, Azmat Ali Khan
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Journal of King Saud University: Science
Subjects:
Docking analyses
AutoDock Vina
AKT serine/threonine kinase
Virtual screening
Pharmacophore modeling
Anticancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364722003676

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http://www.sciencedirect.com/science/article/pii/S1018364722003676

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