Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks
Alaska pollack protein (APP) reduces serum triacylglycerol and body fat accumulation by the enhancement of basal energy expenditure through fast-twitch muscle hypertrophy in rats. However, the effects of APP on brain function have not yet been clarified. In the present study, we investigated the e...
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| Format: | Article |
| Language: | English |
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Japan Poultry Science Association
2012-07-01
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| Series: | The Journal of Poultry Science |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/49/3/49_171/_pdf/-char/en |
| _version_ | 1797816199302610944 |
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| author | Shozo Tomonaga Fuminori Kawabata Junki Yoshida Yumi Ogino Tomoko Tsuji Mitsuhiro Furuse |
| author_facet | Shozo Tomonaga Fuminori Kawabata Junki Yoshida Yumi Ogino Tomoko Tsuji Mitsuhiro Furuse |
| author_sort | Shozo Tomonaga |
| collection | DOAJ |
| description | Alaska pollack protein (APP) reduces serum triacylglycerol and body fat accumulation by the enhancement of basal energy expenditure through fast-twitch muscle hypertrophy in rats. However, the effects of APP on brain function have not yet been clarified. In the present study, we investigated the effects of orally administered APP on the brain levels of 3-methoxy-4-hydroxyphenylglycol (MHPG), which is a metabolite of norepinephrine (NE) and can be used as an index of NE activity, in fasting chicks. Fasting stress significantly decreased plasma glucose, uric acid, triacylglycerol, proline and ornithine while MHPG levels in the brain and plasma corticosterone concentration were not affected. APP dose-dependently decreased MHPG level in the diencephalon, telencephalon and optic lobe. Plasma uric acid, alanine, β-alanine, arginine, anserine, aspartate, asparagine, glycine, histidine, isoleucine, leucine, lysine, 1-methylhistidine, 3-methylhisitidine, ornithine, proline, taurine and valine were dose-dependently increased with the increase of APP. It has been reported that some of them are known to centrally reduce the stress-induced behaviors of chicks. These results suggest that orally administered APP could influence brain NE activity through increase in amino acids to protect against stress conditions. |
| first_indexed | 2024-03-13T08:34:09Z |
| format | Article |
| id | doaj.art-9bc25e9425184b06a045affd61a34560 |
| institution | Directory Open Access Journal |
| issn | 1346-7395 1349-0486 |
| language | English |
| last_indexed | 2024-03-13T08:34:09Z |
| publishDate | 2012-07-01 |
| publisher | Japan Poultry Science Association |
| record_format | Article |
| series | The Journal of Poultry Science |
| spelling | doaj.art-9bc25e9425184b06a045affd61a345602023-05-31T01:15:34ZengJapan Poultry Science AssociationThe Journal of Poultry Science1346-73951349-04862012-07-0149317117710.2141/jpsa.011143jpsaAlaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting ChicksShozo Tomonaga0Fuminori Kawabata1Junki Yoshida2Yumi Ogino3Tomoko Tsuji4Mitsuhiro Furuse5Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, JapanHuman Life Science R&D Center, Nippon Suisan Kaisha, Ltd., JapanLaboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, JapanLaboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, JapanHuman Life Science R&D Center, Nippon Suisan Kaisha, Ltd., JapanLaboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, JapanAlaska pollack protein (APP) reduces serum triacylglycerol and body fat accumulation by the enhancement of basal energy expenditure through fast-twitch muscle hypertrophy in rats. However, the effects of APP on brain function have not yet been clarified. In the present study, we investigated the effects of orally administered APP on the brain levels of 3-methoxy-4-hydroxyphenylglycol (MHPG), which is a metabolite of norepinephrine (NE) and can be used as an index of NE activity, in fasting chicks. Fasting stress significantly decreased plasma glucose, uric acid, triacylglycerol, proline and ornithine while MHPG levels in the brain and plasma corticosterone concentration were not affected. APP dose-dependently decreased MHPG level in the diencephalon, telencephalon and optic lobe. Plasma uric acid, alanine, β-alanine, arginine, anserine, aspartate, asparagine, glycine, histidine, isoleucine, leucine, lysine, 1-methylhistidine, 3-methylhisitidine, ornithine, proline, taurine and valine were dose-dependently increased with the increase of APP. It has been reported that some of them are known to centrally reduce the stress-induced behaviors of chicks. These results suggest that orally administered APP could influence brain NE activity through increase in amino acids to protect against stress conditions.https://www.jstage.jst.go.jp/article/jpsa/49/3/49_171/_pdf/-char/en3-methoxy-4-hydroxyphenylglycolalaska pollack proteinamino acidschicks |
| spellingShingle | Shozo Tomonaga Fuminori Kawabata Junki Yoshida Yumi Ogino Tomoko Tsuji Mitsuhiro Furuse Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks The Journal of Poultry Science 3-methoxy-4-hydroxyphenylglycol alaska pollack protein amino acids chicks |
| title | Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks |
| title_full | Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks |
| title_fullStr | Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks |
| title_full_unstemmed | Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks |
| title_short | Alaska Pollack Protein Decreases Brain 3-methoxy-4-hydroxyphenylglycol Levels in Fasting Chicks |
| title_sort | alaska pollack protein decreases brain 3 methoxy 4 hydroxyphenylglycol levels in fasting chicks |
| topic | 3-methoxy-4-hydroxyphenylglycol alaska pollack protein amino acids chicks |
| url | https://www.jstage.jst.go.jp/article/jpsa/49/3/49_171/_pdf/-char/en |
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