Optimization of the Pharmacokinetic Profile of [<sup>99m</sup>Tc]Tc-N<sub>4</sub>-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence

Optimization of the Pharmacokinetic Profile of [<sup>99m</sup>Tc]Tc-N<sub>4</sub>-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence

Current radiolabeled gastrin-releasing peptide receptor (GRPR) ligands usually suffer from high accumulation in GRPR-positive organs (pancreas, stomach), limiting tumor-to-background contrast in the abdomen. In novel N<sub>4</sub>-bombesin derivatives this was addressed by substitutions...

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Bibliographic Details
Main Authors: Thomas Günther, Matthias Konrad, León Stopper, Jan-Philip Kunert, Sebastian Fischer, Roswitha Beck, Angela Casini, Hans-Jürgen Wester
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
GRPR
technetium-99m
pharmacophore-modified compounds
prostate cancer
breast cancer
Online Access:https://www.mdpi.com/1424-8247/15/9/1133

Internet

https://www.mdpi.com/1424-8247/15/9/1133

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