Targeting Germinal Matrix Hemorrhage–Induced Overexpression of Sodium‐Coupled Bicarbonate Exchanger Reduces Posthemorrhagic Hydrocephalus Formation in Neonatal Rats

Targeting Germinal Matrix Hemorrhage–Induced Overexpression of Sodium‐Coupled Bicarbonate Exchanger Reduces Posthemorrhagic Hydrocephalus Formation in Neonatal Rats

BackgroundGerminal matrix hemorrhage (GMH) is a leading cause of mortality and lifelong morbidity in preterm infants. Posthemorrhagic hydrocephalus (PHH) is a common complication of GMH. A sodium‐coupled bicarbonate exchanger (NCBE) encoded by solute carrier family 4 member 10 gene is expressed on t...

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Bibliographic Details
Main Authors: Qian Li, Yan Ding, Paul Krafft, Weifeng Wan, Feng Yan, Guangyong Wu, Yixin Zhang, Qunling Zhan, John H. Zhang
Format: Article
Language:English
Published: Wiley 2018-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
brain
germinal matrix hemorrhage
hemorrhage
iron overload
iron‐responsive element‐binding protein 2
neonatal ischemia
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.007192

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.117.007192

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