Downregulation of CD94/NKG2A inhibitory receptors on CD8<sup>+ </sup>T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts
<p>Abstract</p> <p>The CD94/NKG2A heterodimer is a natural killer receptor (NKR), which inhibits cell-mediated cytotoxicity upon interaction with MHC class I gene products. It is expressed by NK cells and by a small fraction of activated CD8<sup>+ </sup>T lymphocytes. A...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-10-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/4/1/72 |