Biogenesis of Weibel-Palade bodies in von Willebrand’s disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation

Background Mutations of cysteine residues in von Willebrand factor are known to reduce the storage and secretion of this factor, thus leading to reduced antigen levels. However, one cysteine mutation, p.Cys2773Ser, has been found in patients with type 2A(IID) von Willebrand’s disease who have normal...

Ful tanımlama

Detaylı Bibliyografya
Asıl Yazarlar: Jiong-Wei Wang, Dafna J. Groeneveld, Guy Cosemans, Richard J. Dirven, Karine M. Valentijn, Jan Voorberg, Pieter H. Reitsma, Jeroen Eikenboom
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Ferrata Storti Foundation 2012-06-01
Seri Bilgileri:Haematologica
Online Erişim:https://haematologica.org/article/view/6324