Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease

Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ). It affects cognition and leads to memory impairment. The mitochondrial translocator protein (TSPO) plays an essential role in maintaining mitochondrial homeostasis and has been implicated in several neu...

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Bibliographic Details
Main Authors: Arpit Kumar Pradhan, Tatjana Neumüller, Claudia Klug, Severin Fuchs, Martin Schlegel, Markus Ballmann, Katharina Johanna Tartler, Antoine Pianos, Maria Sanchez Garcia, Philippe Liere, Michael Schumacher, Matthias Kreuzer, Rainer Rupprecht, Gerhard Rammes
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02630-z

Internet

https://doi.org/10.1038/s41398-023-02630-z

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