Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ). It affects cognition and leads to memory impairment. The mitochondrial translocator protein (TSPO) plays an essential role in maintaining mitochondrial homeostasis and has been implicated in several neu...
Main Authors: | Arpit Kumar Pradhan, Tatjana Neumüller, Claudia Klug, Severin Fuchs, Martin Schlegel, Markus Ballmann, Katharina Johanna Tartler, Antoine Pianos, Maria Sanchez Garcia, Philippe Liere, Michael Schumacher, Matthias Kreuzer, Rainer Rupprecht, Gerhard Rammes |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-10-01
|
Series: | Translational Psychiatry |
Online Access: | https://doi.org/10.1038/s41398-023-02630-z |
Similar Items
-
18 kDa Translocator Protein TSPO Is a Mediator of Astrocyte Reactivity
by: Benjamin B. Tournier, et al.
Published: (2023-08-01) -
Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain
by: Jie Liu, et al.
Published: (2022-01-01) -
Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells
by: Stefanie Bader, et al.
Published: (2023-03-01) -
Neurogenic Potential of the 18-kDa Mitochondrial Translocator Protein (TSPO) in Pluripotent P19 Stem Cells
by: Laura González-Blanco, et al.
Published: (2021-10-01) -
Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers
by: Hendris Wongso, et al.
Published: (2024-03-01)