Structural heterogeneity of the ion and lipid channel TMEM16F

Structural heterogeneity of the ion and lipid channel TMEM16F

Abstract Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation and substrate translocation remains...

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Bibliographic Details
Main Authors: Zhongjie Ye, Nicola Galvanetto, Leonardo Puppulin, Simone Pifferi, Holger Flechsig, Melanie Arndt, Cesar Adolfo Sánchez Triviño, Michael Di Palma, Shifeng Guo, Horst Vogel, Anna Menini, Clemens M. Franz, Vincent Torre, Arin Marchesi
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44377-7

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https://doi.org/10.1038/s41467-023-44377-7

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