Oleanolic acid attenuates TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells

Oleanolic acid attenuates TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells

Abstract Background Epithelial-to-mesenchymal transition (EMT) plays an important role in the progression of renal interstitial fibrosis, which finally leads to renal failure. Oleanolic acid (OA), an activator of NF-E2-related factor 2 (Nrf2), is reported to attenuate renal fibrosis in mice with uni...

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Bibliographic Details
Main Authors: Wei-ming He, Jia-qi Yin, Xu-dong Cheng, Xun Lu, Li Ni, Yi Xi, Gui-dong Yin, Guo-yuan Lu, Wei Sun, Ming-gang Wei
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Oleanolic acid
EMT
TGF-β1
Nrf2
Klotho
Online Access:http://link.springer.com/article/10.1186/s12906-018-2265-y

Internet

http://link.springer.com/article/10.1186/s12906-018-2265-y

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