The Number of Donor-Specific IL-21 Producing Cells Before and After Transplantation Predicts Kidney Graft Rejection

The Number of Donor-Specific IL-21 Producing Cells Before and After Transplantation Predicts Kidney Graft Rejection

Interleukin (IL)-21 supports induction and expansion of CD8+ T cells, and can also regulate the differentiation of B cells into antibody-producing plasma cells. We questioned whether the number of circulating donor-specific IL-21 producing cells (pc) can predict kidney transplant rejection, and eval...

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Bibliographic Details
Main Authors: Nicole M. van Besouw, Lin Yan, Ronella de Kuiper, Mariska Klepper, Derek Reijerkerk, Marjolein Dieterich, Dave L. Roelen, Frans H. J. Claas, Marian C. Clahsen-van Groningen, Dennis A. Hesselink, Carla C. Baan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
IL-21
kidney transplantation
rejection
biomarker
Elispot
end-stage renal disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00748/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00748/full

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