Solvent Vibrations as a Proxy of the Telomere G-Quadruplex Rearrangements across Thermal Unfolding

Solvent Vibrations as a Proxy of the Telomere G-Quadruplex Rearrangements across Thermal Unfolding

G-quadruplexes (G4s) are noncanonical forms of DNA involved in many key genome functions. Here, we exploited UV Resonance Raman scattering to simultaneously explore the vibrational behavior of a human telomeric G4 (Tel22) and its aqueous solvent as the biomolecule underwent thermal melting. We found...

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Bibliographic Details
Main Authors: Valeria Libera, Federico Bianchi, Barbara Rossi, Francesco D’Amico, Claudio Masciovecchio, Caterina Petrillo, Francesco Sacchetti, Alessandro Paciaroni, Lucia Comez
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplex
hydrogen bonding
resonant Raman spectroscopy
circular dichroism
hydration water
Online Access:https://www.mdpi.com/1422-0067/23/9/5123

Internet

https://www.mdpi.com/1422-0067/23/9/5123

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