Enhanced Dissolution of Sildenafil Citrate Using Solid Dispersion with Hydrophilic Polymers: Physicochemical Characterization and In Vivo Sexual Behavior Studies in Male Rats

Enhanced Dissolution of Sildenafil Citrate Using Solid Dispersion with Hydrophilic Polymers: Physicochemical Characterization and In Vivo Sexual Behavior Studies in Male Rats

Sildenafil citrate (SLC) is a frequently used medication (Viagra®) for the treatment of erectile dysfunction (ED). Due to its poor solubility, SLC suffers from a delayed onset of action and poor bioavailability. Hence, the aim of the proposed work was to prepare and evaluate solid dispersions (SDs)...

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Bibliographic Details
Main Authors: Mohammed F. Aldawsari, Md. Khalid Anwer, Mohammed Muqtader Ahmed, Farhat Fatima, Gamal A. Soliman, Saurabh Bhatia, Ameeduzzafar Zafar, M. Ali Aboudzadeh
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Polymers
Subjects:
erectile dysfunction
Kolliphor® P188
Kollidon® 30
Kollidon®-VA64
polymer
sildenafil citrate
Online Access:https://www.mdpi.com/2073-4360/13/20/3512

Internet

https://www.mdpi.com/2073-4360/13/20/3512

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