Circulating Tumour DNA Analysis for Tumour Genome Characterisation and Monitoring Disease Burden in Extramedullary Multiple Myeloma

Circulating Tumour DNA Analysis for Tumour Genome Characterisation and Monitoring Disease Burden in Extramedullary Multiple Myeloma

Mutational characterisation in extramedullary multiple myeloma (EM-MM) patients is challenging due to inaccessible EM plasmacytomas, unsafe nature of multiple biopsies and the spatial and temporal genomic heterogeneity apparent in MM (Graphical abstract). Conventional monitoring of disease burden is...

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Bibliographic Details
Main Authors: Sridurga Mithraprabhu, Shreerang Sirdesai, Maoshan Chen, Tiffany Khong, Andrew Spencer
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
cell-free DNA
ctDNA
extramedullary MM
whole exome sequencing
spatial heterogeneity
digital PCR
Online Access:http://www.mdpi.com/1422-0067/19/7/1858

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http://www.mdpi.com/1422-0067/19/7/1858

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