The Flagellin:Allergen Fusion Protein rFlaA:Betv1 Induces a MyD88− and MAPK-Dependent Activation of Glucose Metabolism in Macrophages

The Flagellin:Allergen Fusion Protein rFlaA:Betv1 Induces a MyD88− and MAPK-Dependent Activation of Glucose Metabolism in Macrophages

TLR5 ligand flagellin-containing fusion proteins are potential vaccine candidates for many diseases. A recombinant fusion protein of flagellin A and the major birch pollen allergen Bet v 1 (rFlaA:Betv1) modulates immune responses in vitro and in vivo. We studied the effects of rFlaA:Betv1 on bone ma...

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Bibliographic Details
Main Authors: Yen-Ju Lin, Garibald Papp, Csaba Miskey, Anna Fiedler, Alexandra Goretzki, Sonja Wolfheimer, Jennifer Zimmermann, Peter Crauwels, Zoltán Ivics, Ger van Zandbergen, Stefan Vieths, Stephan Scheurer, Stefan Schülke
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
flagellin
TLR5
allergen
Bet v 1
fusion protein
metabolism
Online Access:https://www.mdpi.com/2073-4409/10/10/2614

Internet

https://www.mdpi.com/2073-4409/10/10/2614

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