First Synthesis of Racemic <i>Trans</i> Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease

First Synthesis of Racemic <i>Trans</i> Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease towards which pleiotropic approach using Multi-Target Directed Ligands is nowadays recognized as probably convenient. Among the numerous targets which are today validated against AD, acetylcholinesterase (ACh) and Monoamine Oxida...

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Bibliographic Details
Main Authors: Benjamin Guieu, Cedric Lecoutey, Rémi Legay, Audrey Davis, Jana Sopkova de Oliveira Santos, Cosimo Damiano Altomare, Marco Catto, Christophe Rochais, Patrick Dallemagne
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
Alzheimer’s disease
acetylcholinesterase
monoamine oxidase
donepezil
rasagiline
MTDL
Online Access:https://www.mdpi.com/1420-3049/26/1/80

Internet

https://www.mdpi.com/1420-3049/26/1/80

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