TDO2 + cancer-associated fibroblasts mediate cutaneous squamous cell carcinoma immune escape via impeding infiltration of CD8 + T cells

Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, originating from the malignant proliferation of squamous epithelial cells. However, its pathogenesis remains unclear. To further explore the mechanisms underlying cSCC, we analyzed the data from one single-cell...

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Bibliographic Details
Main Authors: Fangqi Lu, Guorong Yan, Zijun Zhao, Zhe Zheng, Yuhao Wu, Long Wen, Yeqaing Liu, Qingyu Zeng, Guolong Zhang
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Online Access:https://doi.org/10.1007/s00262-024-03921-0