Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity

Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity

Abstract Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also linked to chronic diseases. Despite its physiological and medical importance, the regulation of Fn14 signaling and turnover is only partly understood. Here, we demonstrate that Fn14 is cleaved wi...

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Bibliographic Details
Main Authors: Gökhan Güner, Marlene Aßfalg, Kai Zhao, Tobias Dreyer, Shibojyoti Lahiri, Yun Lo, Bianca Ionela Slivinschi, Axel Imhof, Georg Jocher, Laura Strohm, Christian Behrends, Dieter Langosch, Holger Bronger, Christopher Nimsky, Jörg W Bartsch, Stanley R Riddell, Harald Steiner, Stefan F Lichtenthaler
Format: Article
Language:English
Published: Springer Nature 2022-10-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
ectodomain shedding
glioblastoma
intramembrane proteolysis
TNR12
Online Access:https://doi.org/10.15252/emmm.202216084

Internet

https://doi.org/10.15252/emmm.202216084

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