PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in Albumin Overload-Induced Renal Tubular Cell Injury

PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in Albumin Overload-Induced Renal Tubular Cell Injury

Background: Proteinuria is an important symptom of chronic kidney disease irrespective of its initial pathogenesis. Mitochondrial dysfunction is an early pathophysiological event in proteinuria-induced tubular damage. Mitophagy, the selective degradation of damaged mitochondria targeted by autophagy...

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Bibliographic Details
Main Authors: Pengpeng Duan, Jin Tan, Yuyang Miao, Qiang Zhang
Format: Article
Language:English
Published: IMR Press 2022-06-01
Series:Frontiers in Bioscience-Landmark
Subjects:
renal tubular epithelial cell
proteinuria
mitochondrial dysfunction
mitophagy
pink1
parkin
Online Access:https://www.imrpress.com/journal/FBL/27/6/10.31083/j.fbl2706184

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https://www.imrpress.com/journal/FBL/27/6/10.31083/j.fbl2706184

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