Wild-type S100A3 and S100A13 restore calcium homeostasis and mitigate mitochondrial dysregulation in pulmonary fibrosis patient-derived cells

Wild-type S100A3 and S100A13 restore calcium homeostasis and mitigate mitochondrial dysregulation in pulmonary fibrosis patient-derived cells

Patients with digenic S100A3 and S100A13 mutations exhibited an atypical and progressive interstitial pulmonary fibrosis, with impaired intracellular calcium homeostasis and mitochondrial dysfunction. Here we provide direct evidence of a causative effect of the mutation on receptor mediated calcium...

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Bibliographic Details
Main Authors: Eid A. Al-Mutairy, Somaya Al Qattan, Mohammed Khalid, Azizah A. Al-Enazi, Maher M. Al-Saif, Faiqa Imtiaz, Khushnooda Ramzan, Vineesh Raveendran, Ayodele Alaiya, Brian F. Meyer, Sergei P. Atamas, Kate S. Collison, Khalid S. Khabar, Jeffrey D. Hasday, Futwan Al-Mohanna
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
lung
fibrosis
calcium
mitochondria
S100A3
S100A13
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1282868/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1282868/full

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