Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery

Cellular uptake, tissue penetration, biodistribution, and biosafety of threose nucleic acids: Assessing in vitro and in vivo delivery

Compared with siRNAs or other antisense oligonucleotides (ASOs), the chemical simplicity, DNA/RNA binding capability, folding ability of tertiary structure, and excellent physiological stability of threose nucleic acid (TNA) motivate scientists to explore it as a novel molecular tool in biomedical a...

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Bibliographic Details
Main Authors: Fei Wang, Ling Sum Liu, Pan Li, Cia Hin Lau, Hoi Man Leung, Y Rebecca Chin, Chung Tin, Pik Kwan Lo
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Materials Today Bio
Subjects:
TNA
Tissue penetration
Pharmacokinetics
Biodistribution
Biosafety
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006422000977

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http://www.sciencedirect.com/science/article/pii/S2590006422000977

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