Low BCL-xL expression in triple-negative breast cancer cells favors chemotherapy efficacy, and this effect is limited by cancer-associated fibroblasts

Low BCL-xL expression in triple-negative breast cancer cells favors chemotherapy efficacy, and this effect is limited by cancer-associated fibroblasts

Abstract Triple negative breast cancers (TNBC) present a poor prognosis primarily due to their resistance to chemotherapy. This resistance is known to be associated with elevated expression of certain anti-apoptotic members within the proteins of the BCL-2 family (namely BCL-xL, MCL-1 and BCL-2). Th...

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Bibliographic Details
Main Authors: Lisa Nocquet, Julie Roul, Chloé C. Lefebvre, Laurine Duarte, Mario Campone, Philippe P. Juin, Frédérique Souazé
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Scientific Reports
Subjects:
Apoptosis
Breast cancer
Cancer-associated fibroblasts
BCL-2 family
Chemotherapy
Online Access:https://doi.org/10.1038/s41598-024-64696-z

Internet

https://doi.org/10.1038/s41598-024-64696-z

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