Downregulation of TCF1 in HIV Infection Impairs T-cell Proliferative Capacity by Disrupting Mitochondrial Function

Downregulation of TCF1 in HIV Infection Impairs T-cell Proliferative Capacity by Disrupting Mitochondrial Function

BackgroundDespite the benefits of antiretroviral therapy (ART) for people with HIV, T-cell dysfunction cannot be fully restored. Metabolic dysregulation is associated with dysfunction of HIV-1-specific T-cells. Exploration of the factors regulating metabolic fitness can help reverse T-cell dysfuncti...

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Bibliographic Details
Main Authors: Hong-Jiao Cai, Jue Shi, Lin-Bo Yin, Jie-Fu Zheng, Ya-Jing Fu, Yong-Jun Jiang, Hong Shang, Zi-Ning Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Microbiology
Subjects:
HIV infection
mitochondrial function
T-cell factor 1
proliferative capacity
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.880873/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.880873/full

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