Scavenging dicarbonyls with 5′-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance

Scavenging dicarbonyls with 5′-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance

Objective: Oxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that covalently bind plasma/cellular proteins, phospholipids, and DNA leading to a...

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Bibliographic Details
Main Authors: Jiansheng Huang, Huan Tao, Patricia G. Yancey, Zoe Leuthner, Linda S. May-Zhang, Ju-Yang Jung, Youmin Zhang, Lei Ding, Venkataraman Amarnath, Dianxin Liu, Sheila Collins, Sean S. Davies, MacRae F. Linton
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Molecular Metabolism
Subjects:
Cholesterol efflux
High-density lipoprotein (HDL)
Malondialdehyde (MDA)
Macrophage
Myeloperoxidase (MPO)
5′-O-Pentyl-pyridoxamine (PPM)
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002204

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http://www.sciencedirect.com/science/article/pii/S2212877822002204

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