TFP5-Mediated CDK5 Activity Inhibition Improves Diabetic Nephropathy via NGF/Sirt1 Regulating Axis

TFP5-Mediated CDK5 Activity Inhibition Improves Diabetic Nephropathy via NGF/Sirt1 Regulating Axis

Diabetic nephropathy (DN) is one of the leading causes of chronic kidney disease (CKD), during which hyperglycemia is composed of the major force for the deterioration to end-stage renal disease (ESRD). However, the underlying mechanism triggering the effect of hyperglycemia on DN is not very clear...

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Bibliographic Details
Main Authors: Shi-Lu Cao, Hong-Yan Luo, Yong-Cai Gao, Xiao-Mei Lan, Shun-Yao Liu, Bo Li, Li Bao, Jing E., Danna Ma, Guo-Qing Zhang, Li-Rong Yang, Xi Bao, Ya-Li Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TFP5
diabetic nephropathy
CDK5
NGF
Sirt1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.829067/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.829067/full

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