Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome

Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome

Dominant loss-of-function mutations in voltage-gated sodium channel NaV1.1 cause Dravet Syndrome, an intractable childhood-onset epilepsy. NaV1.1+/− Dravet Syndrome mice in C57BL/6 genetic background exhibit severe seizures, cognitive and social impairments, and premature death. Here we show that Dr...

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Bibliographic Details
Main Authors: Moran Rubinstein, Ruth E. Westenbroek, Frank H. Yu, Christina J. Jones, Todd Scheuer, William A. Catterall
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
Dravet Syndrome
Sodium channels
Epilepsy
NaV1.1
Interneuron
Action potential threshold
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002897

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http://www.sciencedirect.com/science/article/pii/S0969996114002897

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