BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

Stable integration in the host genome renders murine leukemia virus (MLV)-derived vectors attractive tools for gene therapy. Adverse events in otherwise successful clinical trials caused by proto-oncogene activation due to vector integration hamper their application. MLV and MLV-based vectors integr...

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Bibliographic Details
Main Authors: Sara El Ashkar, Jan De Rijck, Jonas Demeulemeester, Sofie Vets, Paradise Madlala, Katerina Cermakova, Zeger Debyser, Rik Gijsbers
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116303201

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http://www.sciencedirect.com/science/article/pii/S2162253116303201

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