Glycine Signaling in the Framework of Dopamine-Glutamate Interaction and Postsynaptic Density. Implications for Treatment-Resistant Schizophrenia

Glycine Signaling in the Framework of Dopamine-Glutamate Interaction and Postsynaptic Density. Implications for Treatment-Resistant Schizophrenia

Treatment-resistant schizophrenia (TRS) or suboptimal response to antipsychotics affects almost 30% of schizophrenia (SCZ) patients, and it is a relevant clinical issue with significant impact on the functional outcome and on the global burden of disease. Among putative novel treatments, glycine-cen...

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Bibliographic Details
Main Authors: Andrea de Bartolomeis, Mirko Manchia, Federica Marmo, Licia Vellucci, Felice Iasevoli, Annarita Barone
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Psychiatry
Subjects:
N-methyl-d-aspartate
glutamate
dopamine
glycine transporter 1
PSD-95
Homer
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2020.00369/full

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https://www.frontiersin.org/article/10.3389/fpsyt.2020.00369/full

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