Silencing of TGFβ signalling in microglia results in impaired homeostasis
While previous studies had shown the requirement of TGFβ signalling in microglia gene expression, the specificity of the loss-of-function was unclear. Here, Zöller and colleagues generate microglia specific cKO of TGFβ receptor 2, and show dispensable function of Tgfbr2 in microglial survival and th...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06224-y |
| _version_ | 1818855864376754176 |
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| author | Tanja Zöller Artur Schneider Christian Kleimeyer Takahiro Masuda Phani Sankar Potru Dietmar Pfeifer Thomas Blank Marco Prinz Björn Spittau |
| author_facet | Tanja Zöller Artur Schneider Christian Kleimeyer Takahiro Masuda Phani Sankar Potru Dietmar Pfeifer Thomas Blank Marco Prinz Björn Spittau |
| author_sort | Tanja Zöller |
| collection | DOAJ |
| description | While previous studies had shown the requirement of TGFβ signalling in microglia gene expression, the specificity of the loss-of-function was unclear. Here, Zöller and colleagues generate microglia specific cKO of TGFβ receptor 2, and show dispensable function of Tgfbr2 in microglial survival and the requirement of Tgfbr2 in morphological and transcriptional homeostasis of adult microglia. |
| first_indexed | 2024-12-19T08:15:23Z |
| format | Article |
| id | doaj.art-9c07823b43e44ed589f74142507a83ca |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:15:23Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9c07823b43e44ed589f74142507a83ca2022-12-21T20:29:30ZengNature PortfolioNature Communications2041-17232018-10-019111310.1038/s41467-018-06224-ySilencing of TGFβ signalling in microglia results in impaired homeostasisTanja Zöller0Artur Schneider1Christian Kleimeyer2Takahiro Masuda3Phani Sankar Potru4Dietmar Pfeifer5Thomas Blank6Marco Prinz7Björn Spittau8Institute for Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, University of FreiburgInstitute for Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, University of FreiburgInstitute for Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, University of FreiburgInstitute of Neuropathology, Medical Center—University of Freiburg, Faculty of Medicine, University of FreiburgFaculty of Biology, University of FreiburgDepartment of Hematology/Oncology, Faculty of Medicine, University of FreiburgInstitute of Neuropathology, Medical Center—University of Freiburg, Faculty of Medicine, University of FreiburgInstitute of Neuropathology, Medical Center—University of Freiburg, Faculty of Medicine, University of FreiburgInstitute for Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, University of FreiburgWhile previous studies had shown the requirement of TGFβ signalling in microglia gene expression, the specificity of the loss-of-function was unclear. Here, Zöller and colleagues generate microglia specific cKO of TGFβ receptor 2, and show dispensable function of Tgfbr2 in microglial survival and the requirement of Tgfbr2 in morphological and transcriptional homeostasis of adult microglia.https://doi.org/10.1038/s41467-018-06224-y |
| spellingShingle | Tanja Zöller Artur Schneider Christian Kleimeyer Takahiro Masuda Phani Sankar Potru Dietmar Pfeifer Thomas Blank Marco Prinz Björn Spittau Silencing of TGFβ signalling in microglia results in impaired homeostasis Nature Communications |
| title | Silencing of TGFβ signalling in microglia results in impaired homeostasis |
| title_full | Silencing of TGFβ signalling in microglia results in impaired homeostasis |
| title_fullStr | Silencing of TGFβ signalling in microglia results in impaired homeostasis |
| title_full_unstemmed | Silencing of TGFβ signalling in microglia results in impaired homeostasis |
| title_short | Silencing of TGFβ signalling in microglia results in impaired homeostasis |
| title_sort | silencing of tgfβ signalling in microglia results in impaired homeostasis |
| url | https://doi.org/10.1038/s41467-018-06224-y |
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