Caspase-1 and the inflammasome promote polycystic kidney disease progression

Caspase-1 and the inflammasome promote polycystic kidney disease progression

We and others have previously shown that the presence of renal innate immune cells can promote polycystic kidney disease (PKD) progression. In this study, we examined the influence of the inflammasome, a key part of the innate immune system, on PKD. The inflammasome is a system of molecular sensors,...

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Bibliographic Details
Main Authors: Katherine I. Swenson-Fields, Christopher J. Ward, Micaila E. Lopez, Shaneann Fross, Anna L. Heimes Dillon, James D. Meisenheimer, Adib J. Rabbani, Emily Wedlock, Malay K. Basu, Kyle P. Jansson, Peter S. Rowe, Jason R. Stubbs, Darren P. Wallace, Michael P. Vitek, Timothy A. Fields
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
Caspase-1
hydroxychloroquine
IL-1β
IL-18
inflammasome
MYC
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.971219/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.971219/full

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