TIFAB accelerates MLL-AF9−Induced acute myeloid leukemia through upregulation of HOXA9

TIFAB accelerates MLL-AF9−Induced acute myeloid leukemia through upregulation of HOXA9

Summary: We previously showed stabilization of NIK−induced activation of NF-κB non-canonical signaling suppresses MLL-AF9−induced AML. In the current study, we demonstrate that deletion of NF-κB non-canonical RelB prevents the inhibitory effect of NIK stabilization in MLL-AF9 AML. Mechanistically, R...

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Bibliographic Details
Main Authors: Jinming Zhao, Yan Xiu, Lin Fu, Qianze Dong, Nicholas Borcherding, Yang Wang, Qingchang Li, Nilushi S. De Silva, Ulf Klein, Brendan F. Boyce, Chen Zhao
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221013961

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http://www.sciencedirect.com/science/article/pii/S2589004221013961

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