Regulation of platelet membrane protein shedding in health and disease

Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ectodomain fragments that are subsequently dete...

Full description

Bibliographic Details
Main Authors: Amanda E. Au, Emma C. Josefsson
Format: Article
Language:English
Published: Taylor & Francis Group 2017-05-01
Series:Platelets
Subjects:
Online Access:http://dx.doi.org/10.1080/09537104.2016.1203401