Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity

Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity

While T helper (Th) cells play a crucial role in host defense, an imbalance in Th effector subsets due to dysregulation in their differentiation and expansion contribute to inflammatory disorders. Here, we show that Casz1, whose function is previously unknown in CD4+ T cells, coordinates Th differen...

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Bibliographic Details
Main Authors: Natarajan Bhaskaran, Zhihui Liu, Senthil S. Saravanamuthu, Chunhua Yan, Ying Hu, Lijin Dong, Peggy Zelenka, Lixin Zheng, Vassili Bletsos, Rachel Harris, Brenna Harrington, Aaron Weinberg, Carol J. Thiele, Fengchun Ye, Pushpa Pandiyan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
Th17
transcriptional regulation
T helper
cytokine
Th1*
CD4 differentiation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00184/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00184/full

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