Reticulocyte Binding Protein Homologue 5 is a target of balancing selection in the Plasmodium falciparum population of Papua New Guinea

Reticulocyte Binding Protein Homologue 5 is a target of balancing selection in the Plasmodium falciparum population of Papua New Guinea

Plasmodium falciparum Reticulocyte Binding Protein Homologue (RH5), a leading malaria vaccine candidate, is essential for erythrocyte invasion by the parasite, interacting with the human host receptor, basigin. RH5 has a small number of polymorphisms relative to other blood-stage antigens, and in vi...

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Bibliographic Details
Main Authors: Myo T. Naung, Elijah Martin, Wilson Wong, Zahra Razook, Digjaya Utama, Andrew J. Guy, Shannon Takala Harrison, Alan F. Cowman, Enmoore Lin, Benson Kiniboro, Moses Laman, Ivo Mueller, Alyssa E. Barry
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Parasitology
Subjects:
Plasmodium falciparum
RH5
vaccine
polymorphisms
haplotypes
immune escape
Online Access:https://www.frontiersin.org/articles/10.3389/fpara.2023.1288867/full

Internet

https://www.frontiersin.org/articles/10.3389/fpara.2023.1288867/full

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