Proteasome inhibition reduces plasma cell and antibody secretion, but not angiotensin II-induced hypertension

Proteasome inhibition reduces plasma cell and antibody secretion, but not angiotensin II-induced hypertension

IntroductionDepletion of mature B cells affords protection against experimental hypertension. However, whether B cell-mediated hypertension is dependent on differentiation into antibody-secreting cells (ASCs) remains unclear. Using the proteasome inhibitor, bortezomib, the present study tested the e...

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Bibliographic Details
Main Authors: Hericka Bruna Figueiredo Galvao, Quynh Nhu Dinh, Jordyn M. Thomas, Flavia Wassef, Henry Diep, Alex Bobik, Christopher G. Sobey, Grant R. Drummond, Antony Vinh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
hypertension
bortezomib
antibody secreting cells
immunoglobulins
angiotensin II
proteasome inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1184982/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1184982/full

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