Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice

Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice

Abstract Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory. NF1 mouse models (Nf1 heterozygous null mutants; Nf1 +/−) displayed enhanced MAPK activity in the hippocampus and resulted in memory de...

Full description

Bibliographic Details
Main Authors: Lei Chen, Tatiana Serdyuk, Beimeng Yang, Shuai Wang, Shiqing Chen, Xixia Chu, Xu Zhang, Jinjing Song, Hechen Bao, Chengbin Zhou, Xiang Wang, Shuangle Dong, Lulu Song, Fujun Chen, Guang He, Lin He, Ying Zhou, Weidong Li
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Molecular Brain
Subjects:
Nf1 +/− mouse model
MAPK oscillation
Hippocampal rhythmic oscillations
Local field potentials
Spike activity
Online Access:http://link.springer.com/article/10.1186/s13041-017-0309-8

Internet

http://link.springer.com/article/10.1186/s13041-017-0309-8

Similar Items