Desmin Knock-Out Cardiomyopathy: A Heart on the Verge of Metabolic Crisis

Desmin Knock-Out Cardiomyopathy: A Heart on the Verge of Metabolic Crisis

Desmin mutations cause familial and sporadic cardiomyopathies. In addition to perturbing the contractile apparatus, both desmin deficiency and mutated desmin negatively impact mitochondria. Impaired myocardial metabolism secondary to mitochondrial defects could conceivably exacerbate cardiac contrac...

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Bibliographic Details
Main Authors: Barbara Elsnicova, Daniela Hornikova, Veronika Tibenska, David Kolar, Tereza Tlapakova, Benjamin Schmid, Markus Mallek, Britta Eggers, Ursula Schlötzer-Schrehardt, Viktoriya Peeva, Carolin Berwanger, Bettina Eberhard, Hacer Durmuş, Dorothea Schultheis, Christian Holtzhausen, Karin Schork, Katrin Marcus, Jens Jordan, Thomas Lücke, Peter F. M. van der Ven, Rolf Schröder, Christoph S. Clemen, Jitka M. Zurmanova
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
desmin
desminopathy
cardiomyopathy
mitochondriopathy
desmin knock-out metabolism
glucose
Online Access:https://www.mdpi.com/1422-0067/23/19/12020

Internet

https://www.mdpi.com/1422-0067/23/19/12020

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