Hybrid Pharmacophore- and Structure-Based Virtual Screening Pipeline to Identify Novel EGFR Inhibitors That Suppress Non-Small Cell Lung Cancer Cell Growth

Hybrid Pharmacophore- and Structure-Based Virtual Screening Pipeline to Identify Novel EGFR Inhibitors That Suppress Non-Small Cell Lung Cancer Cell Growth

Dysregulated epidermal growth factor receptor (EGFR) expression is frequently observed in non-small cell lung cancer (NSCLC) growth and metastasis. Despite recent successes in the development of tyrosine kinase inhibitors (TKIs), inevitable resistance to TKIs has led to urgent calls for novel EGFR i...

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Bibliographic Details
Main Authors: Chia-Wei Weng, Chi-Hsuan Wei, Jeng-Yuan Tsai, Yi-Hua Lai, Gee-Chen Chang, Jeremy J. W. Chen
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
lung cancer
EGFR inhibitor
pharmacophore model
virtual screening
molecular docking
Online Access:https://www.mdpi.com/1422-0067/23/7/3487

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https://www.mdpi.com/1422-0067/23/7/3487

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