Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H

Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H

Stimulator of interferon genes (STING) plays a central role in innate immune responses to viral and intracellular bacterial infections, and cellular damage. STING is a cytosolic sensor of cyclic dinucleotides (CDNs) including those produced by pathogenic bacteria and those arising endogenously as pr...

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Bibliographic Details
Main Authors: Melissa M. Walker, Soojin Kim, William J. Crisler, Kimberlie Nguyen, Laurel L. Lenz, John C. Cambier, Andrew Getahun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
STING
cGAS
cyclic dinucleotide
allelic variants
infection
cancer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00238/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00238/full

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