Both 3,5-Diiodo-L-Thyronine and 3,5,3′-Triiodo-L-Thyronine Prevent Short-term Hepatic Lipid Accumulation via Distinct Mechanisms in Rats Being Fed a High-Fat Diet

Both 3,5-Diiodo-L-Thyronine and 3,5,3′-Triiodo-L-Thyronine Prevent Short-term Hepatic Lipid Accumulation via Distinct Mechanisms in Rats Being Fed a High-Fat Diet

3,3′,5-triiodo-L-thyronine (T3) improves hepatic lipid accumulation by increasing lipid catabolism but it also increases lipogenesis, which at first glance appears contradictory. Recent studies have shown that 3,5-diiodothyronine (T2), a natural thyroid hormone derivative, also has the capacity to s...

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Bibliographic Details
Main Authors: Rosalba Senese, Federica Cioffi, Pieter de Lange, Cristina Leanza, Liliana F. Iannucci, Elena Silvestri, Maria Moreno, Assunta Lombardi, Fernando Goglia, Antonia Lanni
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Physiology
Subjects:
thyroid hormones receptors
thyroid hormones
thyroid hormone response element
lipogenesis
lipid metabolism
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00706/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00706/full

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