The Veterinary Anti-Parasitic Selamectin Is a Novel Inhibitor of the <i>Mycobacterium tuberculosis</i> DprE1 Enzyme

The Veterinary Anti-Parasitic Selamectin Is a Novel Inhibitor of the <i>Mycobacterium tuberculosis</i> DprE1 Enzyme

Avermectins are macrocyclic lactones with anthelmintic activity. Recently, they were found to be effective against <i>Mycobacterium tuberculosis</i>, which accounts for one third of the worldwide deaths from antimicrobial resistance. However, their anti-mycobacterial mode of action remai...

Full description

Bibliographic Details
Main Authors: José Manuel Ezquerra-Aznárez, Giulia Degiacomi, Henrich Gašparovič, Giovanni Stelitano, Josè Camilla Sammartino, Jana Korduláková, Paolo Governa, Fabrizio Manetti, Maria Rosalia Pasca, Laurent Roberto Chiarelli, Santiago Ramón-García
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
avermectins
selamectin
tuberculosis
<i>Mycobacterium tuberculosis</i>
drug repurposing
Online Access:https://www.mdpi.com/1422-0067/23/2/771

Internet

https://www.mdpi.com/1422-0067/23/2/771

Similar Items