Different N-Glycosylation Sites Reduce the Activity of Recombinant DSPAα2

Different N-Glycosylation Sites Reduce the Activity of Recombinant DSPAα2

Bat plasminogen activators α2 (DSPAα2) has extremely high medicinal value as a powerful natural thrombolytic protein. However, wild-type DSPAα2 has two N-glycosylation sites (N185 and N398) and its non-human classes of high-mannose-type N-glycans may cause immune responses in vivo. By mutating the N...

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Bibliographic Details
Main Authors: Huakang Peng, Mengqi Wang, Nan Wang, Caifeng Yang, Wenfang Guo, Gangqiang Li, Sumei Huang, Di Wei, Dehu Liu
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Current Issues in Molecular Biology
Subjects:
N-glycosylation site
plasminogen activator
fibrin sensitivity
DSPAα2
<i>Pichia</i> <i>pastoris</i>
Online Access:https://www.mdpi.com/1467-3045/44/9/270

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https://www.mdpi.com/1467-3045/44/9/270

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