Choice of Differentiation Media Significantly Impacts Cell Lineage and Response to CFTR Modulators in Fully Differentiated Primary Cultures of Cystic Fibrosis Human Airway Epithelial Cells

Choice of Differentiation Media Significantly Impacts Cell Lineage and Response to CFTR Modulators in Fully Differentiated Primary Cultures of Cystic Fibrosis Human Airway Epithelial Cells

In vitro cultures of primary human airway epithelial cells (hAECs) grown at air–liquid interface have become a valuable tool to study airway biology under normal and pathologic conditions, and for drug discovery in lung diseases such as cystic fibrosis (CF). An increasing number of different differe...

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Bibliographic Details
Main Authors: Vinciane Saint-Criq, Livia Delpiano, John Casement, Jennifer C. Onuora, JinHeng Lin, Michael A. Gray
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
differentiation media
in vitro airway model
epithelium physiology
RNA-sequencing
pH
ion transport
Online Access:https://www.mdpi.com/2073-4409/9/9/2137

Internet

https://www.mdpi.com/2073-4409/9/9/2137

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