Dexamethasone-Induced Myeloid-Derived Suppressor Cells Prolong Allo Cardiac Graft Survival through iNOS- and Glucocorticoid Receptor-Dependent Mechanism

Dexamethasone-Induced Myeloid-Derived Suppressor Cells Prolong Allo Cardiac Graft Survival through iNOS- and Glucocorticoid Receptor-Dependent Mechanism

How to induce immune tolerance without long-term need for immunosuppressive drugs has always been a central problem in solid organ transplantation. Modulating immunoregulatory cells represents a potential target to resolve this problem. Myeloid-derived suppressor cells (MDSCs) are novel key immunore...

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Bibliographic Details
Main Authors: Yang Zhao, Xiao-Fei Shen, Ke Cao, Jie Ding, Xing Kang, Wen-xian Guan, Yi-tao Ding, Bao-rui Liu, Jun-Feng Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
myeloid-derived suppressor cells
immune tolerance
dexamethasone
iNOS
glucocorticoid receptor
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00282/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00282/full

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