The rare DRB1*04:08-DQ8 haplotype is the main HLA class II genetic driver and discriminative factor of Early-onset Type 1 diabetes in the Portuguese population

The rare DRB1*04:08-DQ8 haplotype is the main HLA class II genetic driver and discriminative factor of Early-onset Type 1 diabetes in the Portuguese population

IntroductionEarly-onset Type 1 diabetes (EOT1D) is considered a disease subtype with distinctive immunological and clinical features. While both Human Leukocyte Antigen (HLA) and non-HLA variants contribute to age at T1D diagnosis, detailed analyses of EOT1D-specific genetic determinants are still l...

Full description

Bibliographic Details
Main Authors: Iris Caramalho, Paula Matoso, Dário Ligeiro, Tiago Paixão, Daniel Sobral, Ana Laura Fitas, Catarina Limbert, Jocelyne Demengeot, Carlos Penha-Gonçalves
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
Type 1 diabetes
age of onset
T1D endotypes
Early-onset Type 1 diabetes
HLA class II
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1299609/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1299609/full

Similar Items