The nexus of dynamic T cell states and immune checkpoint blockade therapy in the periphery and tumor microenvironment

The nexus of dynamic T cell states and immune checkpoint blockade therapy in the periphery and tumor microenvironment

Immune checkpoint blockade (ICB) therapies, that is, using monoclonal antibodies to reinvigorate tumor-reactive, antigen-specific T cells from the inhibitory effects of CTLA-4, PD-1 and PD-L1 immune checkpoints, have revolutionized the therapeutic landscape of modern oncology. However, only a subset...

Full description

Bibliographic Details
Main Authors: Hong Luo, Wenxiang Wang, Jia Mai, Rutie Yin, Xuyu Cai, Qintong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
peripheral blood
T cell
TCR repertoire
immune checkpoint blockade
PD-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267918/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267918/full

Similar Items