Expanded Proteomic Survey of the Human Parasite Leishmania major Focusing on Changes in Null Mutants of the Golgi GDP-Mannose/Fucose/Arabinopyranose Transporter LPG2 and of the Mitochondrial Fucosyltransferase FUT1

Expanded Proteomic Survey of the Human Parasite Leishmania major Focusing on Changes in Null Mutants of the Golgi GDP-Mannose/Fucose/Arabinopyranose Transporter LPG2 and of the Mitochondrial Fucosyltransferase FUT1

ABSTRACT The trypanosomatid protozoan parasite Leishmania has a significant impact on human health globally. Understanding the pathways associated with virulence within this significant pathogen is critical for identifying novel vaccination and chemotherapy targets. Within this study we leverage an...

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Bibliographic Details
Main Authors: Gloria Polanco, Nichollas E. Scott, Lon F. Lye, Stephen M. Beverley
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
N-linked glycans
N-linked glycoconjugates
trypanosomatid protozoan parasite
fucose
glycoproteome
kinetoplast
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03052-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03052-22

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