Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation

Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation

Summary: To mount an adaptive immune response, dendritic cells must migrate to lymph nodes to present antigens to T cells. Critical to 3D migration is the nucleus, which is the size-limiting barrier for migration through the extracellular matrix. Here, we show that inflammatory activation of dendrit...

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Bibliographic Details
Main Authors: Harry Warner, Giulia Franciosa, Guus van der Borg, Britt Coenen, Felix Faas, Claire Koenig, Rinse de Boer, René Classens, Sjors Maassen, Maksim V. Baranov, Shweta Mahajan, Deepti Dabral, Frans Bianchi, Niek van Hilten, Herre Jelger Risselada, Wouter H. Roos, Jesper Velgaard Olsen, Laia Querol Cano, Geert van den Bogaart
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724001943

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http://www.sciencedirect.com/science/article/pii/S2211124724001943

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