YAP promotes autophagy and progression of gliomas via upregulating HMGB1

YAP promotes autophagy and progression of gliomas via upregulating HMGB1

Abstract Background Due to the hypoxia and nutrient deficiency microenvironment, glioblastoma (GBM) exhibits high autophagy activity and autophagy plays an important role in the progression of GBM. However, the molecular mechanism of autophagy in GBM progression remains unclear. The aim of this stud...

Full description

Bibliographic Details
Main Authors:	Min Zhao, Yu Zhang, Yang Jiang, Kai Wang, Xiang Wang, Ding Zhou, Yan Wang, Rutong Yu, Xiuping Zhou
Format:	Article
Language:	English
Published:	BMC 2021-03-01
Series:	Journal of Experimental & Clinical Cancer Research
Subjects:	Glioma YAP Autophagy HMGB1 Progression
Online Access:	https://doi.org/10.1186/s13046-021-01897-8

Similar Items

SU4312 Represses Glioma Progression by Inhibiting YAP and Inducing Sensitization to the Effect of Temozolomide
by: Xu Wang, et al.
Published: (2022-08-01)

β-catenin-mediated YAP signaling promotes human glioma growth
by: Yan Wang, et al.
Published: (2017-09-01)

Paradoxical role of high mobility group box 1 in glioma: a suppressor or a promoter?
by: Richard A. Seidu, et al.
Published: (2017-03-01)

HMGB1-mediated apoptosis and autophagy in ischemic heart diseases
by: Eleonora Foglio, et al.
Published: (2019-09-01)

Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP–RIPK1–NF-κB axis and influencing autophagy
by: Chunran Pan, et al.
Published: (2024-03-01)

The relationship between HMGB1 and autophagy in the pathogenesis of diabetes and its complications
by: Kun Yang, et al.
Published: (2023-03-01)

HMGB1 Mediated Inflammation and Autophagy Contribute to Endometriosis
by: Jingying Huang, et al.
Published: (2021-03-01)

Role of Hippo/YAP signaling in irradiation-induced glioma cell apoptosis
by: Xu X, et al.
Published: (2019-08-01)

HMGB1 mediates lipopolysaccharide-induced macrophage autophagy and pyroptosis
by: Jiawei Shang, et al.
Published: (2023-01-01)

YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas
by: Wei Xu, et al.
Published: (2021-01-01)

HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair
by: Xing Guo, et al.
Published: (2018-08-01)

Subcellular localization of HMGB1 in human cholangiocarcinoma: correlation with tumor stage
by: Nattawan Suwannakul, et al.
Published: (2021-11-01)

Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization
by: Zhuang Li, et al.
Published: (2022-02-01)

YAP1 Regulates the YAP1/AR/PSA Axis through Autophagy in Castration-Resistant Prostate Cancer and Mediates T-Cell Immune and Inflammatory Cytokine Infiltration
by: Youzhi Wang, et al.
Published: (2024-03-01)

NGF Signaling Interacts With the Hippo/YAP Pathway to Regulate Cervical Cancer Progression
by: Lijun Wang, et al.
Published: (2021-10-01)

HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells
by: Wenwen Chai, et al.
Published: (2019-07-01)

Conditional Knock out of High-Mobility Group Box 1 (HMGB1) in Rods Reduces Autophagy Activation after Retinal Detachment
by: Bing X. Ross, et al.
Published: (2021-08-01)

miR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways
by: Yu Y, et al.
Published: (2019-10-01)

Oxidative Stress-mediated HMGB1 Biology
by: Yan eYu, et al.
Published: (2015-04-01)

CD44 promotes hepatocellular carcinoma progression via upregulation of YAP
by: Jun Zhang, et al.
Published: (2021-11-01)

Cytosolic HMGB1 Mediates LPS-Induced Autophagy in Microglia by Interacting with NOD2 and Suppresses Its Proinflammatory Function
by: Seung-Woo Kim, et al.
Published: (2022-08-01)

Sitagliptin inhibits the survival, stemness and autophagy of glioma cells, and enhances temozolomide cytotoxicity
by: Fangting You, et al.
Published: (2023-06-01)

Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells
by: Ying Shi, et al.

Autophagy as a Potential Therapy for Malignant Glioma
by: Angel Escamilla-Ramírez, et al.
Published: (2020-07-01)

Morin Hydrate Sensitizes Hepatoma Cells and Xenograft Tumor towards Cisplatin by Downregulating PARP-1-HMGB1 Mediated Autophagy
by: Mahendra Pal Singh, et al.
Published: (2020-11-01)

WIP-YAP/TAZ as A New Pro-Oncogenic Pathway in Glioma
by: Sergio Rivas, et al.
Published: (2018-06-01)

HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle
by: Xiaofan Yang, et al.
Published: (2018-12-01)

UM-164, a Dual Inhibitor of c-Src and p38 MAPK, Suppresses Proliferation of Glioma by Reducing YAP Activity
by: Huizhe Xu, et al.
Published: (2022-10-01)

Upregulated Expression of Cancer-Derived Immunoglobulin G Is Associated With Progression in Glioma
by: Guohui Wang, et al.
Published: (2021-10-01)

GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression
by: Chaolong Yan, et al.
Published: (2024-04-01)

Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis
by: Caijun Zha, et al.
Published: (2020-02-01)

Ischemic postconditioning protects against acute kidney injury after limb ischemia reperfusion by regulating HMGB1 release and autophagy
by: Zhongdi Liu, et al.
Published: (2023-12-01)

A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth
by: Marie Mayrhofer, et al.
Published: (2017-01-01)

Johnny on the Spot-Chronic Inflammation Is Driven by HMGB1
by: Carolina M. Gorgulho, et al.
Published: (2019-07-01)

New Autophagy-Ferroptosis Gene Signature Predicts Survival in Glioma
by: Liwei Zhou, et al.
Published: (2021-11-01)

Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and DevelopmentSummary
by: Shuyi Chen, et al.
Published: (2022-01-01)

Repositioning Linagliptin for the Mitigation of Cadmium-Induced Testicular Dysfunction in Rats: Targeting HMGB1/TLR4/NLRP3 Axis and Autophagy
by: Hany H. Arab, et al.
Published: (2022-07-01)

Increased Expression of YAP Inhibited the Autophagy Level by Upregulating mTOR Signal in the Eutopic ESCs of Endometriosis
by: Tianjiao Pei, et al.
Published: (2022-01-01)

Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma
by: Xue Zhang, et al.
Published: (2017-08-01)

Downregulation of miR-223 promotes HMGB2 expression and induces oxidative stress to activate JNK and promote autophagy in an in vitro model of acute lung injury
by: Hao-Yu Tan, et al.
Published: (2021-11-01)